Research progress on the relationship between early life obesogen exposure and childhood obesity
GAO Lei1, YE Zhen2, WANG Wei1, ZHAO Dong1, XU Peiwei1, ZHANG Ronghua1
1. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China; 2. Zhejiang Zhijiang Life and Health Institute, Hangzhou, Zhejiang 310005, China
摘要儿童肥胖已成为全球公共卫生问题,现有研究表明,生命早期肥胖原暴露已成为儿童肥胖的重要危险因素。目前研究已确认肥胖原可通过内分泌干扰和表观遗传编程等机制影响儿童肥胖发生发展,但在因果链条确立、复合暴露评估和人类跨代遗传验证等方面仍存在争议。近年来,多组学技术、暴露组学分析和多代际追踪队列等新方法,通过整合生物标志物动态监测与社会环境交互作用分析,为构建“暴露-机制-结局”系统研究框架提供了新视角和新方法。本文检索PubMed、Web of Science数据库中截至2025年8月关于生命早期肥胖原暴露与儿童肥胖关联的研究文献,对生命早期肥胖原暴露的健康效应、主要暴露途径与内暴露评估、社会与环境因素的交互与放大效应和肥胖原作用的生物学机制进行综述,并剖析当前研究前沿与挑战,为儿童肥胖的早期防控和精准干预提供理论依据。
Abstract：Childhood obesity has become a global public health issue. Current research indicates that early life obesogen exposure has emerged as a significant risk factor for childhood obesity. While obesogens have been confirmed to influence the development and progression of childhood obesity through mechanisms such as endocrine disruption and epigenetic programming, controversies remain regarding the establishment of causal relationships, assessment of combined exposures, and validation of transgenerational effects in humans. In recent years, novel approaches including multi-omics technologies, exposome-based analysis, and multigenerational cohort studies have integrated dynamic biomarker monitoring with analyses of social-environmental interactions, offering new perspectives and methodologies for constructing a systematic "exposure-mechanism-outcome" research framework. This article reviews literature from PubMed and Web of Science up to August 2025 on the association between early life obesogen exposure and childhood obesity, summarizing evidence on the health effects of early life obesogen exposure, major exposure pathways and internal exposure assessment, interactions and amplifying effects of social and environmental factors, as well as the biological mechanisms underlying obesogen action. It further examines current research frontiers and challenges, aiming to provide a theoretical foundation for early prevention and precision intervention of childhood obesity.
高雷, 叶真, 王玮, 赵栋, 徐沛维, 章荣华. 生命早期肥胖原暴露与儿童肥胖关系的研究进展[J]. 预防医学, 2026, 38(1): 48-54.
GAO Lei, YE Zhen, WANG Wei, ZHAO Dong, XU Peiwei, ZHANG Ronghua. Research progress on the relationship between early life obesogen exposure and childhood obesity. Preventive Medicine, 2026, 38(1): 48-54.
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