Effects of quality of life in patients with intermediate and advanced lung cancer undergoing different treatment regimens
WANG Yue1, HUANG Xiaotong2, ZHAO Fei1, Ding Lili1, WU Bingyi1
1. School of Management, Shandong Second Medical University, Weifang, Shandong 261053, China; 2. School of Nursing, Shandong Second Medical University, Weifang, Shandong 261053, China
Abstract：Objective To examine the impacts of chemotherapy/radiotherapy, targeted therapy, and combined treatment on the quality of life in patients with intermediate and advanced lung cancer. Methods The patients with intermediate and advanced lung cancer undergoing chemotherapy/radiotherapy, targeted therapy, and combined treatment for the first time were recruited from a tertiary hospital in Weifang City, Shandong Province, using a quota sampling method in September 2023. Basic information was collected using a general information questionnaire, and the quality of life was assessed using the Chinese version of Functional Assessment of Cancer Therapy-General. The investigation started on the 7th day of treatment, and the follow-ups were conducted at 3 and 6 months. The quality of life in patients with different treatment regimens and at different treatment time were compared using repeated measure analysis of variance. Results There were 26 chemotherapy/radiotherapy patients, 32 targeted therapy patients, and 95 combination therapy patients. There were no significant differences in age, gender, place of residence, education level, self-rated economic status, medical insurance, pathological type and disease stage among the three treatment regimens (all P>0.05). The repeated measure analysis of variance showed an interaction effect between time and group among patients receiving the three treatment regimens (P<0.05). The quality of life scores of patients receiving combination therapy decreased with extended treatment time (all P<0.05). The quality of life scores of patients receiving targeted therapy at 3 and 6 months were lower than those treated for 7 days (both P<0.05). No significant differences were observed in quality of life scores among chemotherapy/radiotherapy patients with different treatment durations (all P>0.05). At 3 and 6 months, patients receiving combination therapy had lower quality of life scores compared to those receiving chemotherapy/radiotherapy or targeted therapy (all P<0.05). Conclusion The decline in quality of life for patients with intermediate and advanced lung cancer undergoing chemotherapy/radiotherapy and targeted therapy is less than that for patients receiving combined therapy.
王越, 黄晓彤, 赵菲, 丁莉莉, 吴炳义. 中晚期肺癌患者不同治疗方案对生命质量的影响[J]. 预防医学, 2025, 37(3): 272-275.
WANG Yue, HUANG Xiaotong, ZHAO Fei, Ding Lili, WU Bingyi. Effects of quality of life in patients with intermediate and advanced lung cancer undergoing different treatment regimens. Preventive Medicine, 2025, 37(3): 272-275.
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