Multimodal non-pharmacological interventions for Alzheimer's disease: a review
ZHOU Ying1, LI Lian2, BIAN Guolin2
1. School of Public Health, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, China; 2. The Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang 315201, China
Abstract：Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive dysfunction and behavioral impairments. Currently, the treatment mainly relies on pharmacotherapy, yet its effectiveness is limited and accompanied by adverse reactions. Multimodal non-pharmacological interventions (MNPI), which combine two or more non-pharmacological intervention approaches, can synergistically improve cognitive function, neuropsychiatric symptoms, activities of daily living, and quality of life in AD patients, and offers advantages of safety, cost-effectiveness and simplicity. This article reviews MNPI-related literature published domestically and internationally from 2018 to 2024, and focuses on the application of cognitive training, physical activity, and other combined intervention methods in MNPI, providing the reference for developing personalized interventions for AD.
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