Abstract：Objective To analyze the correlations of systolic blood pressure (SBP) with uric acid, blood lipid and blood glucose in adults, so as to provide the evidence for blood pressure management and early prevention of cardiovascular diseases. Methods Based on the China Health and Nutrition Survey, data of participants in 2004 and 2009 was collected, including demographic characteristics, blood pressure, uric acid, blood lipid and blood glucose. Participants with SBP<140 mmHg both in 2004 and 2009 were divided into the continuously normal group, participants with SBP≥140 mmHg in 2004 and <140 mmHg in 2009 were divided into the reduced group, participants with SBP<140 mmHg in 2004 and ≥140 mmHg in 2009 were divided into the elevated group, and participants with SBP≥140 mmHg both in 2004 and 2009 were divided into the continuously high group. Multivariable logistic regression model was used to analyze the correlations of SBP with uric acid, blood lipid and blood glucose. Results A total of 5 086 subjects were included in this study with a mean age of (48.0±7.2) years, including 2 374 males (46.67%) and 2 712 women (53.33%). The median (interquartile range) of SBP was 117.00 (13.33) mmHg in the continuously normal group, 146.67 (15.33) mmHg in the reduced group, 122.67 (12.00) mmHg in the elevated group and 150.67 (18.66) mmHg in the continuously high group. Multivariable logistic regression analysis showed that compared with the continuously normal group, the reduced group was correlated with abnormal fasting blood glucose (OR=1.383, 95%CI: 1.008-1.896); the elevated group was correlated with abnormal uric acid (OR=1.495, 95%CI: 1.195-1.869), abnormal low density lipoprotein cholesterol (OR=1.226, 95%CI: 1.030-1.460), abnormal triglyceride (OR=1.446, 95%CI: 1.203-1.739) and abnormal total cholesterol (OR=1.261, 95%CI: 1.057-1.504); the continuously high group was correlated with abnormal uric acid (OR=1.603, 95%CI: 1.188-2.164), abnormal triglyceride (OR=1.619, 95%CI: 1.253-2.093) and abnormal fasting blood glucose (OR=1.565, 95%CI: 1.166-2.100), adjusting for confounding factors (gender, age, marital status, etc.). Conclusion The increase of SBP in adults were correlated with uric acid, blood lipid and blood glucose.
[1] POULTER N R,PRABHAKARAN D,CAULFIELD M.Hypertension[J].Lancet,2015,386(9995):801-812. [2] 黄文,汤佳良,陈康康,等.绍兴市心血管疾病高危人群危险因素聚集分析[J].预防医学,2023,35(4):298-302,330. [3] 迟相林. 收缩压重要还是舒张压重要?如何治疗单纯收缩期高血压和单纯舒张期高血压?[J].中华高血压杂志,2019,27(7):615-621. [4] 邓晓丽,钟灵,冯丽.血压变异性与冠心病患者冠状动脉非钙化斑块负荷的相关性研究[J].中国医学前沿杂志(电子版),2021,13(1):85-88. [5] 程臻,胡瑜,刘雨濛.体检人群中体重指数与血压、血脂、血糖及血尿酸的相关性分析[J].当代医学,2021,27(1):22-25. [6] AF GEIJERSTAM P,ENGVALL J,ÖSTGREN C J,et al.Home blood pressure compared with office blood pressure in relation to dysglycemia[J].Am J Hypertens,2022,35(9):810-819. [7] 王淑霞,周怡.维吾尔族高血压病病人血尿酸水平与高血压及动脉硬化的关系研究[J].中西医结合心脑血管病杂志,2018,16(19):2847-2850. [8] 高尿酸血症相关疾病诊疗多学科共识专家组.中国高尿酸血症相关疾病诊疗多学科专家共识[J].中华内科杂志,2017,56(3):235-248. [9] JI X,ZHAO H,WANG M,et al.Study of correlations between metabolic risk factors,PWV and hypertension in college students[J]. Clin Exp Hypertens,2020,42(4):376-380. [10] LIN X,WANG X,LI X,et al.Gender- and age-specific differences in the association of hyperuricemia and hypertension: a cross-sectional study[J]. Int J Endocrinol,2019,2019:1-9. [11] NISHIDA Y,TAKAHASHI Y,SUSA N,et al.Comparative effect of angiotensin II type I receptor blockers on serum uric acid in hypertensive patients with type 2 diabetes mellitus:a retrospective observational study[J]. Cardiovasc Diabetol,2013,12:1-8. [12] FENECH G,RAJZBAUM G,MAZIGHI M,et al.Serum uric acid and cardiovascular risk:state of the art and perspectives[J]. Joint Bone Spine,2014,81(5):392-397. [13] 李娇龙,翟晋慧,候利,等. 老年退休人群尿酸及血脂水平与高血压的关系分析[J]. 预防医学情报杂志,2020,36(11):1486-1490. [14] 杨顺昱,江戈,杨兰,等. 血脂、血尿酸及血清25-羟基维生素D水平与老年高血压及其疾病分级的相关性[J]. 中国老年学杂志,2022,42(20):4915-4917. [15] BALA C,GHEORGHE-FRONEA O,POP D,et al.The association between six surrogate insulin resistance indexes and hypertension:a population-based study[J]. Metab Syndr Relat Disord,2019,17(6):328-333. [16] 王瑾,张彬艳,商苏杭,等.西安市农村居民高血压与血脂水平的相关性研究[J].兰州大学学报(医学版),2018,44(6):14-19. [17] 沈益妹,章奇,朱新凤,等.湖州市血压控制未达标高血压患者慢性病共病及影响因素分析[J].预防医学,2023,35(6):541-545,550. [18] 郭荣荣,谢艳霞,郑佳,等.农村非高血压人群空腹血糖与血压因果关系分析[J].中国公共卫生,2020,36(5):789-792. [19] 郭荣荣,谢艳霞,郑佳,等.高血压人群中血糖与血压的因果关系研究[J].中国预防医学杂志,2019,20(9):769-774.
