Association between smoking and ankylosing spondylitis: a Mendelian randomization study
YANG Hong1, LIU Wei1, LUO Peiyang2, SONG Jie1, JIANG Yuqing1, HE Zhixing2, YE Ding1, MAO Yingying1
1. School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; 2. Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
Abstract：Objective To evaluate the association of smoking with the risk of ankylosing spondylitis (AS) using a Mendelian randomization (MR) approach. Methods A total of 16 383 186 AS-associated single nucleotide polymorphisms (SNPs), 378 smoking initiation associated SNPs and 126 lifetime smoking score-associated SNPs were collected from three large-scale genome-wide association studies (GWAS). The association of smoking phenotypes with the risk of AS was examined using inverse-variance weighted (IVW) with AS as a outcome variable, smoking initiation and lifetime smoking score as exposure factors and SNPs with strong associations with smoking as instrumental variables, and sensitivity analyses were performed with maximum likelihood-based method, MR pleiotropy residual sum and outlier (MR-PRESSO) test and MR-Egger regression analysis. Results A 33.5% increased risk of AS was found among genetically predicted smokers relative to non-smokers (OR=1.335, 95%CI: 1.059-1.682), and an increase in predicted lifetime smoking by per standard deviation resulted in a 101.4% increased risk of AS (OR=2.014, 95%CI: 1.341-3.024). The maximum likelihood-based method and MR-PRESSO test showed consistent correlated effect estimations and MR-Egger regression analysis identified no evidence of pleiotropy. Conclusion It is genetically predicted that smoking is associated with an increased risk of AS.
杨红, 刘溦, 骆沛洋, 宋杰, 蒋雨晴, 何志兴, 叶丁, 毛盈颖. 吸烟与强直性脊柱炎关联的孟德尔随机化研究[J]. 预防医学, 2023, 35(1): 1-5.
YANG Hong, LIU Wei, LUO Peiyang, SONG Jie, JIANG Yuqing, HE Zhixing, YE Ding, MAO Yingying. Association between smoking and ankylosing spondylitis: a Mendelian randomization study. Preventive Medicine, 2023, 35(1): 1-5.
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