Research progress of insulin resistance and hyperinsulinemia promoting pancreatic cancer
LI Shanshan, ZHAO Yulan
Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital to School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
Abstract：Pancreatic cancer is a common digestive tract carcinoma. It is strongly occult and lack of early diagnostic indicators, and the patients have quite low survival rates. The pathogenesis of pancreatic cancer remains unclear. It has been reported that smoking, family history, diabetes mellitus and obesity are associated with the incidence of pancreatic cancer; moreover, type 2 diabetes mellitus (T2DM) often occur as a comorbidity. Insulin resistance and compensatory hyperinsulinemia are the main metabolic characteristics of T2DM, which play an important role in the development and progression of pancreatic cancer. The molecular mechanisms of insulin resistance and hyperinsulinemia promoting pancreatic cancer are reviewed in this paper, in order to provide the evidence for the prevention and treatment of pancreatic cancer.
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