Abstract：Fine particulate matter (PM2.5) not only directly damages lung tissue, but also can be absorbed into blood through alveolar capillaries, which is toxic to the cardiovascular system. PM2.5 can affect lipid metabolism, endothelial function, coagulation and thrombosis through oxidative stress, inflammatory reaction, autonomic nervous dysfunction and immune regulation abnormality, so that it promote arteriosclerosis, plaque instability, and increase the morbidity and mortality of cardiovascular disease. We reviewed the effects and mechanisms of PM2.5 on arteriosclerosis, in order to provide the evidence for the studies into prevention of cardiovascular diseases caused by air pollution.
陈欢, 刘永生,尹扬光. PM2.5对动脉粥样硬化的影响及机制[J]. 预防医学, 2021, 33(10): 1017-1021.
CHEN Huan, LIU Yongsheng, YIN Yangguang. The effect of fine particulate matter on atherosclerosis and its mechanism. Preventive Medicine, 2021, 33(10): 1017-1021.
[1] PRUNICKI K,CAUWENBERGHS N,ATAAM J A.Immune biomarkers link air pollution exposure to blood pressure in adolescents[J/OL]. Environ Health,2020,19(1)[2021-06-02].https://pubmed. ncbi. nlm. nih. gov/33066786.DOI:10.1186/s12940-020-00662-2. [2] HUYNH Q,MARWICK T H,VENKATARAMAN P,et al.Long-term exposure to ambient air pollution is associated with coronary artery calcification among asymptomatic adults[J/OL].Eur Heart J Cardiovasc Imaging,2020[2021-06-02].https://pubmed. ncbi.nlm.nih.gov/32356862.DOI:10.1093/ehjci/jeaa073. [3] RANZANNI O T,MILA C,SANCHEZ M,et al.Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project[J].Int J Epidemiol,2020,49(1):69-79. [4] AKINTOYE E,SHI L H,OBAITAN I,et al.Association between fine particulate matter exposure and subclinical atherosclerosis: a meta-analysis[J].Eur J Prev Cardiol,2016,23(6):602-612. [5] WANG S Q,WANG F F,YANG L X,et al.Effects of coal-fired PM2.5 on the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoE-/- mice[J/OL].BMC Pharmacol Toxicol,2020,21(1)[2021-06-02]. https://pubmed.ncbi.nlm.nih.gov/32384920.DOI:10.1186/s40360-020-00411-8. [6] ZHU X C,ZHAO P,LU Y G,et al.Potential injurious effects of the fine particulate PM2.5 on the progression of atherosclerosis in ApoE-deficient mice by activating platelets and leukocytes[J].Arch Med Sci,2019,15(1):250-261. [7] WAN Q,LIU Z Y,YANG Y P.Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway[J/OL].BMC Complement Altern Med,2018,18(1)[2021-06-02]. https://pubmed.ncbi.nlm.nih.gov/29728095.DOI:10.1186/s12906-018-2206-9. [8] HENNIG F,GEISEL M H,KALSCH H,et al.Air pollution and progression of atherosclerosis in different vessel beds-results from a prospective cohort study in the Ruhr Area,Germany[J/OL].Environ Health Perspect,2020,128(10)[2021-06-02]. https://pubmed.ncbi.nlm. nih.gov/33017176.DOI:10.1289/EHP7077. [9] WANG M,HOU Z H,XU H,et al.Association of estimated long-term exposure to air pollution and traffic proximity with a marker for coronary atherosclerosis in a nationwide study in China[J/OL].JAMA Netw Open,2019,2(6)[2021-06-02]. https://pubmed.ncbi.nlm. nih.gov/31251382.DOI:10.1001/jamanetworkopen.2019.6553. [10] KAUFMAN J D,ADAR S D,BARR R G,et al.Association between air pollution and coronary artery calcification within six metropolitan areas in the USA(the multi-ethnic study of atherosclerosis and air pollution):a longitudinal cohort study[J].Lancet,2016,388(10045):696-704. [11] HARTIALA J,BRETON C V,TANG W H W,et al.Ambient air pollution is associated with the severity of coronary atherosclerosis and incident myocardial infarction in patients undergoing elective cardiac evaluation[J/OL].J Am Heart Assoc,2016,5(8)[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/ 27468926.DOI: 10.1161/JAHA.116.003947. [12] BROOK R D,NEWBY D E,RAJAGOPALAN S.Air pollution and cardiometabolic disease:an update and call for clinical trials[J]. Am J Hypertens,2017,31(1):1-10. [13] MANNUCCI P M,HARARI S,FRANCHINI M.Novel evidence for a greater burden of ambient air pollution on cardiovascular disease[J].Haematologica,2019,104(12):2349-2357. [14] STACHYRA K,KIEPURA A,OLSZANECKI R.Air pollution and atherosclerosis--a brief review of mechanistic links between atherogenesis and biological actions of inorganic part of particulate matter[J].Folia Med Cracov,2017,57(3):37-46. [15] 袁鹏辉,吴书慧,朱敏洁,等.细颗粒物(PM2.5)对心肌梗死的影响[J].华中科技大学学报(医学版),2018,47(6):759-762. [16] SHI J,DENG H P,ZHANG M.Curcumin pretreatment protects against PM2.5-induced oxidized low-density lipoprotein-mediated oxidative stress and in ammation in human microvascular endothelial cells[J].Mol Med Rep,2017,16(3):2588-2594. [17] GUAN L F,GANG X K,SHEN J M,et al.PM2.5 inhalation induces intracranial atherosclerosis which may be ameliorated by omega 3 fatty acids[J].Oncotarget,2017,9(3):3765-3778. [18] HOLME S A N,SIGSGAARD T,HOLME J A,et al.Effects of particulate matter on atherosclerosis: a link via high-density lipoprotein (HDL) functionality?[J/OL].Part Fibre Toxicol,2020,17(1)[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/32753036.DOI:10.1186/s12989-020-00367-x. [19] HAJAT A,ALLISON M,DIEZ-ROUX A V,et al.Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation:a repeat-measures analysis in the Multi-Ethnic Study of Atherosclerosis(MESA)[J].Epidemiology,2015,26(3):310-320. [20] LIANG S,ZHANG J Y,NING R H,et al.The critical role of endothelial function in fine particulate matter-induced atherosclerosis[J/OL].Part Fibre Toxicol,2020,17(1)[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/33276797.DOI:10.1186/s12989-020-00391-x. [21] WU P C,CHENG T J,KUO C P,et al.Transient risk of ambient fine particulate matter on hourly cardiovascular events in Tainan City, Taiwan[J/OL].PLoS One,2020,15(8)[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/32822436.DOI:10.1371/journal.pone.0238082. [22] 吴卫东,安珍,贵双俊,等.PM2.5暴露促进动脉粥样硬化发生发展的研究进展[J].山东大学学报(医学版),2018,56(11):18-26. [23] 臧文秀,陈宇,陈鹏,等.PM2.5引起氧化应激反应及对心血管疾病的影响[J].吉林医学,2018,39(4):751-754. [24] PEI Y L,JIANG R F,ZOU Y Z,et al.Effects of fine particulate matter(PM2.5)on systemic oxidative stress and cardiac function in ApoE-/- mice[J/OL].Int J Environ Res Public Health,2016,13(5)[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/27187431.DOI:10.3390/ijerph13050484. [25] DONG L,HU R M,YANG D D,et al.Fine particulate matter(PM2.5)upregulates expression of inflammasome NLRP1 via ROS/NF-κB signaling in HaCaT cells[J].Int J Med Sci,2020,17(14):2200-2206. [26] LI W Y,WILKER E H,DORANS K S,et al.Short-term exposure to air pollution and biomarkers of oxidative stress:the framingham heart study[J/OL].J Am Heart Assoc,2016,5(5)[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/27126478.DOI:10.1161/JAHA.115.002742. [27] 胡阳阳,陈欣.PM2.5对心血管疾病影响的进展研究[J].中国心血管病研究,2020,18(4):374-378. [28] GONDALIA R,HOLLIDAY K M,BALDASSARI A,et al.Leukocyte traits and exposure to ambient particulate matter air pollution in the Women＇s Health Initiative and Atherosclerosis Risk in Communities Study[J/OL].Environ Health Perspect,2020,128(1)[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/31903802.DOI:10.1289/EHP5360. [29] XIE Y Q,BO L,JIANG S,et al.Individual PM2.5 exposure is associated with the impairment of cardiac autonomic modulation in general residents[J].Environ Sci Pollut Res Int,2016,23(10):10255-10261. [30] LIN S Y,HSU W H,LIN C L,et al.Association of exposure to fine-particulate air pollution and acidic gases with incidence of nephrotic syndrome[J/OL].Int J Environ Res Public Health,2018,15(12)[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/30558173.DOI:10.3390/ijerph15122860. [31] WU Q,XU Z W,DAN Y L,et al.Association between traffic-related air pollution and hospital readmissions for rheumatoid arthritis in Hefei,China: a time-series study[J/OL].Environ Pollut,2021,268[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/33049484.DOI:10.1016/j.envpol.2020.115628. [32] JUNG C R,CHUANG W T,CHEN W T,et al.Long-term exposure to traffic-related air pollution and systemic lupus erythematosus in Taiwan:a cohort study[J].Sci Total Environ,2019,668:342-349. [33] ZHANG Y W,NI H,BAI L J,et al.The short-term association between air pollution and childhood asthma hospital admissions in urban areas of Hefei city in China:a time-series study[J].Environ Res,2019,169:510-516. [34] GE J,YANG H L,LU X X,et al.Combined exposure to formaldehyde and PM2.5:hematopoietic toxicity and molecular mechanism in mice[J/OL].Environ Int,2020,144[2021-06-02].https://pubmed.ncbi.nlm.nih.gov/32861163.DOI:10.1016/j.envint.2020.106050. [35] WAN Q,LIU Z Y,YANG M,et al.Acceleratory effects of ambient fine particulate matter on the development and progression of atherosclerosis in apolipoprotein E knockout mice by down-regulating CD4+CD25+Foxp3+regulatory T cells[J].Toxicol Lett,2019,316:27-34.
