Abstract：Objective To analyze the association between recombinant solute carrier family 11, member 1 ( SLC11A1 ) rs17235409 polymorphism and treatment failure of pulmonary tuberculosis, so as to provide the basis for the prevention and treatment of pulmonary tuberculosis. Methods The patients with pulmonary tuberculosis registered for treatment at the Urumqi Center for Disease Control and Prevention in 2019 was recruited and collected demographic, clinical and treatment information from National Infectious Diseases Reporting System. The polymorphism of SLC11A1 rs17235409 was detected by multiple ligase chain reaction and Hardy-Weinberg balance test was performed. The multivariate logistic regression analysis was conducted for the association between rs17235409 and the treatment outcome of tuberculosis. Results A total of 731 cases of pulmonary tuberculosis patients were enrolled, and 37 cases failed, with a failure rate of 5.06%. The failure rate of the patients with G/A was 8.55%, with G/G was 4.23%. The results of multivariate logistic regression analysis showed that the patients with G/A were more likely to fail in the treatment than those with G/G ( OR=2.213, 95%CI: 1.041-4.702 ). The males with G/A were more likely to fail in the treatment than those with G/G ( OR=2.547, 95%CI: 1.021-6.356 ). Conclusion The rs17235409 polymorphism of SLC11A1 is associated with the failure of tuberculosis treatment, and the patients with G/A are more likely to fail.
刘亚洁, 张燕, 陈阳贵, 张为胜, 马丽, 曹明芹. SLC11A1基因多态性与肺结核治疗失败的关联分析[J]. 预防医学, 2021, 33(6): 563-567.
LIU Yajie, ZHANG Yan, CHEN Yanggui, ZHANG Weisheng, MA Li, CAO Mingqin. The association between SLC11A1 gene polymorphism and treatment failure of pulmonary tuberculosis. Preventive Medicine, 2021, 33(6): 563-567.
[1] ARAVINDAN P P.Host genetics and tuberculosis: theory of genetic polymorphism and tuberculosis[J].Lung India,2019,36(3):244-252. [2] 朱圭娜,侯怀哲,尹媛婕,等.SLC11A1基因多态性与宁夏南部人群肺结核易感性研究[J].中国防痨杂志,2017,39(10):1080-1087. [3] KHALILULLAH S A,HARAPAN H,HASAN N A,et al.Host genome polymorphisms and tuberculosis infection: what we have to say?[J].Egypt J Chest Dis Tuberc,2014,63(1):173-185. [4] LIU Y,ZHAO E,ZHU L,et al.3'UTR polymorphisms in NRAMP1 are associated with the susceptibility to pulmonary tuberculosis: a MOOSE-compliant meta-analysis[J/OL].Medicine(Baltimore),2019,98:e15955.[2021-03-05]. https://pubmed.ncbi.nlm.nih.gov/33101421/.DOI:10.1097/MD.0000000000015955. [5] 中华人民共和国国家卫生健康委办公厅.中国结核病预防控制工作技术规范(2020年版) [EB/OL].(2020-04-02) [2021-03-05]. http://guide.medlive.cn/guideline/21035. [6] GEBREZGABIHER G,ROMHA G,EJETA E,et al.Treatment outcome of tuberculosis patients under directly observed treatment short course and factors affecting outcome in southern Ethiopia: a five-year retrospective study[J/OL].PLoS One, 2016, 11(2): e050560.[2021-03-05].https://pubmed.ncbi.nlm.nih.gov/26918458/.DOI: 10.1371/journal.pone.0150560. [7] 杨丹,文进,刘年强,等.新疆维吾尔族人群肺结核治疗结局影响因素研究[J].中国全科医学,2019,22(12):1413-1418. [8] 郭净,刘忠达,张尊敬,等.丽水市耐多药肺结核治疗效果及影响因素分析[J].预防医学,2018,30(10):987-991. [9] ALENE K A,VINEY K,YI H,et al.Comparison of the validity of smear and culture conversion as a prognostic marker of treatment outcome in patients with multidrug-resistant tuberculosis[J].PLoS One,2018,13(5): e0197880. [2021-03-05].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965863/. DOI: 10.1371/journal.pone.0197880. [10] MELESE A,ZELEKE B.Factors associated with poor treatment outcome of tuberculosis in Debre Tabor, northwest Ethiopia[J].BMC Res Notes,2018,11(1):25.[2021-03-05].https://pubmed.ncbi.nlm.nih.gov/29335004/.DOI: 10.1186/s13104-018-3129-8. [11] 马丽,古丽娜扎尔·艾克拜尔,陈阳贵,等.涂阳肺结核患者2月末痰菌阳性的影响因素分析[J].现代预防医学,2019,46(8):1487-1489,1493. [12] ZENG J,XIE L,LUO H,et al.The epigenetic modifications of genes associated with tuberculosis susceptibility and implications for epi-drugs[J].Crit Rev Eukaryot Gene Expr,2015,25(4):349-362. [13] SALINAS-DELGADO Y,GALAVIZ-HERNANDEZ C,TORAL R G,et al.The D543N polymorphism of the SLCLC11AL/NRAMP1 gene is associated with treatment failure in male patients with pulmonary tuberculosis[J].Drug Metab Pers Ther,2015,30(3):211-214. [14] ALI M K,KARANJA S,KARAMA M.Factors associated with tuberculosis treatment outcomes among tuberculosis patients attending tuberculosis treatment centres in2016-2017 in Mogadishu, Somalia[J].Pan Afr Med J,2017,28:197. [2021-03-05].https://pubmed.ncbi.nlm.nih.gov/29610635/.DOI:10.11604/pamj.2017.28.197.13439. [15] MULUYE A B,KEBAMO S,TEKLIE T,et al.Poor treatment outcomes and its determinants among tuberculosis patients in selected health facilities in east Wollega, western Ethiopia[J].PLoS One,2018,13(10):e0206227. [2021-03-05]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203372/.DOI:10.1371/journal.pone.0206227. [16] 邱玉冰,许琳,杨蕊,等.云南省成功治疗肺结核患者5年复发情况及影响因素研究[J].预防医学,2020,32(6):559-562.
