Abstract：Recent years have witnessed extensive drug resistance of environmental microorganisms due to the abuse of antibiotics. The emergence and global spread of antibiotic resistance genes (ARGs) has led to great potential harms to human health and environment stability. The ARGs in the environment mainly come from the evolution of microorganisms and horizontal gene transfer between strains, and are widely distributed in water, soil and atmosphere. The transmission of ARGs is affected by residual antibiotics, heavy metals and organic compounds in the environment. The existing detection methods for ARGs include the detection of phenotype and genotype of drug-resistant bacteria. The methods based on polymerase chain reaction have been developed, while metagenomics will open another door for more efficient and accurate detection of ARGs. This paper reviews the studies into the source, outcome, transmission, influencing factors and detection of ARGs, in order to provide reference for the management, control and prevention of ARGs in the environment.
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