Abstract：Objective To study the epidemiological characteristics of coronavirus disease 2019 （COVID-19） in Zhoushan, so as to provide reference for improving the prevention and control capability of COVID-19. Methods All the confirmed cases of COVID-19 in Zhoushan, diagnosed according to China’s “COVID-19 diagnosis and treatment plan （fifth version） ” and reported from January 19 to February 17, 2020, were extracted from the infectious disease surveillance system. Data of general information, clinical characteristics, laboratory Results, transmission and detection routes were collected and analyzed. Results By February 17, Ten confirmed cases of COVID-19 in Zhoushan had been reported, including 7 males and 3 females. They were all adults, with an average age of （50.90±15.00） years. Five cases were discharged. The incubation period ranged from 2 to 12 days, with a median of 5 days. The first symptoms were fever （8 cases）, cough （7 cases） and muscle pain （2 cases）. Chest computed tomographic （CT） scans showed ground glass opacities in the lungs of all the cases. Six cases had Wuhan related exposure. SARS-CoV-2 was tested positive in the sputum specimens or throat swabs of all the cases and the faeces of 4 cases. The last suspicious exposure of 5 cases occurred before, and that of another 5 cases occurred after the onset of clinical symptoms in the confirmed maternal cases. Three cases were found in active consultation after clinical symptoms, and another 7 cases were found in the monitoring of close contacts. Conclusions The 10 confirmed cases of COVID-19 reported in Zhoushan are all adults, and most have Wuhan related exposure. SARS-CoV-2 can be detected in the fecal samples, but the existence of fecal-oral transmission needs more research. SARS-CoV-2 has strong infectivity, and may also have infectivity before the onset of symptoms （at the end of incubation period）. Isolation and early detection of close contacts are conducive for early case-finding.
[1] LU H,STRATTON C W,TANG Y W.Outbreak of pneumonia of unknown etiology in Wuhan,China:the mystery and the miracle[J].J Med Virol,2020,92(4):401-402. [2] ZHU N, ZHANG D, WANG W, et al.A novel coronavirus from patients with pneumonia in China, 2019[J]. N Engl J Med, 2020,382(8):727-733. [3] CHAN J F, KOK K H, ZHU Z, et al.Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan[J]. Emerg Microbes Infect, 2020, 9(1):221-236. [4] LI X, ZAI J, WANG X, et al.Potential of large "first generation" human-to-human transmission of 2019-nCoV[J]. J Med Virol. 2020,92(4):448-454. [5] The Lancet.Emerging understandings of 2019-nCoV[J]. Lancet,2020,395(10221):311. [6] 中华人民共和国国家卫生健康委员会.关于印发《新型冠状病毒感染的肺炎诊疗方案(试行第五版)》的通知[EB/OL].(2020-02-05)[2020-02-21].http://www.nhc.gov.cn/yzygj/s7653p/ 202002/3b09b894ac9b4204a79db5b8912d4440.shtml. [7] WANG D, HU B, HU C, et al. Clinical characteristics of 138 hospitalized patients with2019 novel coronavirus-infected pneumonia in Wuhan, China[J/OL]. JAMA(2020-02-07)[2020-02-21].https://jamanetwork.com/journals/jama/fullarticle/2761044. [8] HUANG C, WANG Y, LI X,et al.Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020,395(10223):497-506. [9] LI Q, GUAN X, WU P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia[J/OL]. N Engl J Med(2020-01-29)[2020-02-21].https:// www.nejm.org/doi/10.1056/NEJMoa2001316?url_ver=Z39.88-2003 &rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov. [10] LU C W, LIU X F, JIA Z F.2019-nCoV transmission through the ocular surface must not be ignored[J/OL].Lancet(2020-02-06)[2020-02-21].https://linkinghub.elsevier.com/retrieve/pii/ S0140-6736(20)30313-5. [11] YU P, ZHU J, ZHANG Z D,et al. A familial cluster of infection associated with the2019 novel coronavirus indicating potential person-to-person transmission during the incubation period[J/OL]. J Infect Dis(2020-02-18)[2020-02-21]. https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiaa077. [12] KAMPF G, TODT D, PFAENDER S,et al. Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents[J/OL]. J Hosp Infect(2020-02-06)[2020-02-21]. https : // linkinghub.elsevier.com/retrieve/pii/S0195-6701(20)30046-3. [13] 中华人民共和国国家卫生健康委员会.新型冠状病毒感染的肺炎防控方案(第五版)[Z]. 2020.
