Abstract：Objective To explore the association between coffee intake and all cancer mortality in East Asian populations. Methods We searched literatures which assessed the relationship between coffee intake and cancer mortality in Asian populations published by December 10th,2018 from China National Knowledge Infrastructure,Wanfang Database,VIP Database and PubMed. We conducted category and dose-response meta-analyses using Stata 15.0. Results A total of 335 relevant articles were retrieved; five articles were finally included in the meta-analyses,of which four were carried out in Japanese population and one in Singaporean Chinese population. The total sample size of the five articles was 361 802,and the number of deaths from cancer was 17 664. The results showed that coffee intake reduced the risk of all cancer mortality in East Asian populations（RR=0.93,95%CI：0.87-0.99）. There was no statistical significant association between coffee intake and all cancer mortality in East Asian men（RR=0.94,95%CI：0.77-1.15）. Among East Asian women,coffee consumption reduced the risk of all cancer mortality by 12%（RR=0.88,95%CI：0.81-0.95）. All cancer mortality risk decreased with the increase of coffee intake,and reached the lowest point at one and a half cups of coffee per day（RR=0.92,95%CI：0.86-0.98）. Conclusion Coffee intake reduced the risk of all cancer mortality in East Asian populations,which was obviously found in East Asian women. Drinking one and a half cups of coffee a day had the lowest risk of all cancer mortality.
李迎君, 朱家豪, 范佳耀, 范春红. 咖啡摄入与东亚人群恶性肿瘤死亡风险关联的Meta分析[J]. 预防医学, 2019, 31(6): 549-552,557.
LI Ying-jun, ZHU Jia-hao, FAN Jia-yao, FAN Chun-hong. Meta-analysis of coffee intake and all cancer mortality in East Asian population. Preventive Medicine, 2019, 31(6): 549-552,557.
[1] TORRE L A,BRAY F,SIEGEL R L,et al.Global cancer statistics,2012[J]. CA:A Cancer Journal for Clinicians,2015,65(2):87-108. [2] BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA:A Cancer Journal for Clinicians,2018,68(6):394-424. [3] VAN B P.Coffee or tea? A prospective cohort study on the associations of coffee and tea intake with overall and cause-specific mortality in men versus women[J]. European Journal of Epidemiology,2018,33(2):183-200. [4] GAPSTUR S M,ANDERSON R L,CAMPBELL P T,et al.Associations of coffee drinking and cancer mortality in the Cancer Prevention Study-II[J]. Cancer Epidemiology,Biomarkers & Prevention,2017,26(10):1477-1486. [5] SADO J,KITAMURA T,KITAMURA Y,et al.Association between coffee consumption and all-sites cancer incidence and mortality[J]. Cancer Science,2017,108(10):2079-2087. [6] MALERBA S,TURATI F,GALEONE C,et al.A meta-analysis of prospective studies of coffee consumption and mortality for all causes,cancers and cardiovascular diseases[J]. European Journal of Epidemiology,2013,28(7):527-539. [7] GROSSO G,MICEK A,GODOS J,et al.Coffee consumption and risk of all-cause,cardiovascular,and cancer mortality in smokers and non-smokers:a dose-response meta-analysis[J]. European Journal of Epidemiology,2016,31(12):1191-1205. [8] ORSINI N,LI R,WOLK A,et al.Meta-analysis for linear and nonlinear dose-response relations:examples,an evaluation of approximations,and software[J]. American Journal of Epidemiology,2012,175(1):66-73. [9] SAITO E,INOUE M,SAWADA N,et al.Association of coffee intake with total and cause-specific mortality in a Japanese population:the Japan Public Health Center-based Prospective Study[J]. American Journal of Clinical Nutrition,2015,101(5):1029-1037. [10] ODEGAARD A O,KOH W P,YUAN J M,et al.Beverage habits and mortality in Chinese adults[J]. Journal of Nutrition,2015,145(3):595-604. [11] TAMAKOSHI A,LIN Y,KAWADO M,et al.Effect of coffee consumption on all-cause and total cancer mortality:findings from the JACC study[J]. European Journal of Epidemiology,2011,26(4):2852-2893. [12] SUGIYAMA K,KURIYAMA S,AKHTER M,et al.Coffee consumption and mortality due to all causes,cardiovascular disease,and cancer in Japanese women[J]. Journal of Nutrition,2010, 140(5):1007-1013. [13] SVILAAS A,SAKHI A K,ANDERSEN L F,et al.Intakes of antioxidants in coffee,wine,and vegetables are correlated with plasma carotenoids in humans[J]. Journal of Nutrition,2004, 134(3):562-567. [14] OLTHOF M R,HOLLMAN P C,KATAN M B.Chlorogenic acid and caffeic acid are absorbed in humans[J]. Journal of Nutrition,2001,131(1):66-71. [15] LOPEZ-GARCIA E,VAN R M,QI L,et al.Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women[J]. American Journal of Clinical Nutrition,2006,84(4):888-893.
