Abstract：Objective To investigate the distribution of insulin resistance （HOMA-IR） index and its influencing factors among middle and old aged people with normal glucose and to provide the basis for early screening and prevention of type 2 diabetes. Methods A total of 229 residents were selected with health records showed normal blood glucose （fasting blood glucose < 7.0mmol/L,postprandial 2h blood glucose<11.1 mmol/L） and more than 40 years old from July, 2012 to June,2015. Height,weight, waist and hip circumference, and the fasting plasma glucose （FPG）,insulin （FINS）,low density lipoprotein （LDL）,uric acid,tumor necrosis factor （TNF） and interleukin -6 （IL-6）were recorded to analyze the distribution of HOMA-IR and its influencing factors. Results Totally 229 people were included,of which 113 were male（49.34%）,116 female（50.66%）. The average age was（63.58 + 8.85）years old. The average HOMA-IR index was 0.94 （1.08）and there were 21 people that HOMA-IR exceed the standard （HOMA-IR≥2.68）,accounting for 9.17%.The HOMA-IR index of different gender,age,waist circumference,hip circumference,uric acid in the elderly had significant difference （P < 0.05）.Multiple linear regression analysis showed that HOMA-IR index was positively correlated with female,waist circumference and IL-6 and was negatively correlated with age. Conclusion The possibility of IR was higher in women with relatively low age,female,central obesity and high IL-6 levels among the middle and old aged people with normal blood glucose.
施晓峰, 王三忠, 俞新芬, 沈华, 潘琴梅, 沈知行, 沈耿生, 陈公英. 血糖正常中老年人胰岛素抵抗指数分布及影响因素分析[J]. 预防医学, 2017, 29(5): 460-463.
SHI Xiao-feng, WANG San-zhong, YU Xin-fen, SHEN Hua, PAN Qin-mei, SHEN Zhi-xing, SHEN Di-sheng, CHEN Gong-ying. A study on the correlations study among HOMA-IR, obesity and inflammatory factors among middle aged and elderly population. Preventive Medicine, 2017, 29(5): 460-463.
