Abstract：Objective To investigate the association of genetic variants in the promoter region of UCA1 and its expression level with colorectal cancer，especially to provide basis for UCA1 as a molecular biomarker for colorectal cancer risk. Methods Totally 507 cases of primary colorectal cancer and 503 healthy volunteers were included in the case group and the control group. The single nucleotide polymorphisms of the UCA1 rs7255437 locus were detected in the blood，and the association between the UCA1 rs7255437 polymorphism and the risk of colorectal cancer was analyzed. Bioinformatics method was used to verify the association between UCA1 expression and UCA1 rs7255437 polymorphism with risk of colorectal cancer. Results The results showed that compared with the CC genotype，CT and TT genotypes had an increased risk of colorectal cancer，however the difference was not statistically significant（P>0.05） . Compared with the CC genotype，TT genotype had a 67% decreased risk of advanced colorectal cancer（P<0.05） . The result of bioinformatics analysis showed that the UCA1 expression level of CT and TT carriers in normal transverse colon and small intestinal tissues was higher than that of CC carriers，and the expression level of UCA1 in colorectal cancer tissues in advanced colorectal cancer patients was higher than that of early colorectal cancer patients.Conclusion UCA1 expression and rs7255437 polymorphism are potential molecular markers for the development of colorectal cancer. However，confirmation studies with larger sample size and further mechanistic investigations into the function of UCA1 and its genetic variants are needed.
李迎君，刘冰，景方圆，丁烨，何青芳，钟要红，范春红. UCA1表达水平及其启动子区域rs7255437单核苷酸多态性与结直肠癌的关系[J]. 预防医学, 2018, 30(9): 884-888.
LI Ying-jun，LIU Bing，JING Fang-yuan，DING Ye，HE Qing-fang，ZHONG Yao-hong，FAN Chun-hong. Association of UCA1 expression and rs7255437 polymorphism in UCA1 promoter region with colorectal cancer. Preventive Medicine, 2018, 30(9): 884-888.
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