Abstract：Objective To analyze the occurrence features of adverse event following immunization（AEFI）among children in Shushan，and to evaluate the immunization safety related to vaccines，and the implementation of AEFI information management system.Methods AEFI cases and vaccination data of children in Shushan from 2014 to 2017 were collected by National AEFI Monitoring Information Management system and Vaccination Information system of Anhui Province. Descriptive epidemiological methods were used to analyze the incidence rate of AEFI，the characteristics of cases，the classification and the clinical manifestations.Results 386 cases were reported during 2014 to 2017. The reported incidence rate of AEFI was 30.85 per 100，000 doses，which showed a decreasing trend year by year （P<0.05）. The reported incidence rate of AEFI in male and female was 31.54 per 100，000 doses and 30.07 per 100，000 doses，respectively. The reported incidence rate of AEFI between male and female showed no significant difference（P>0.05）. The reported incidence rate of AEFI in children aged one to two（two was not included） scored the highest，which was 39.44 per 100，000 doses; the reported incidence rate of AEFI in children aged four to five（five was not included） scored the lowest，which was 4.91 per 100，000 doses. In the group one vaccines，the reported incidence rate of AEFI of Leprosy vaccine（65.12 per 100，000 doses），DT vaccine（53.76 per 100，000 doses） and AC meningitis conjugated vaccine（52.02 per 100，000 doses） ranked first，second and third. In the group two vaccines，the reported incidence rate of AEFI of 23-valent pneumonic polysaccharide vaccine （107.99 per 100，000 doses），DTaP-IPV/Hib combination vaccine（105.03 per 100，000 doses） and DTaP-Hib vaccine（51.42 per 100，000 doses） ranked first，second and third. The main reactions of AEFI were fever and redness. Vaccine reactions were often occurred within 1d after vaccination.Conclusions The AEFI monitoring system in Shushan is in good condition. The reported incidence rate of AEFI varies in age and vaccine varieties. Training and digitalizd construction of vaccination outpatient service should be strengthened in order to further improve the quality of vaccination service and AEFI monitoring.
