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预防医学  2020, Vol. 32 Issue (2): 152-154    DOI: 10.19485/j.cnki.issn2096-5087.2020.02.011
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多不饱和脂肪酸与疾病发生风险的孟德尔随机化研究进展
黄慧君, 陈刚, 钱雨, 张凌芝, 徐岚静, 叶丁(综述), 毛盈颖(审校)
浙江中医药大学,浙江 杭州 310053
Progress on the Mendelian randomization studies of polyunsaturated fatty acids and diseases
HUANG Huijun, CHEN Gang, QIAN Yu, ZHANG Lingzhi, XU Lanjing, YE Ding, MAO Yingying
Department of Epidemiology,School of Basic Medical Sciences & Public Health,Zhejiang Chinese Medical University, Hangzhou,Zhejiang 310053,China
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摘要 采用观察性流行病学方法研究多不饱和脂肪酸(PUFAs)与疾病发生风险的关系存在一定局限性。以遗传变异为工具变量的孟德尔随机化(MR)研究能有效避免观察性流行病学研究中混杂因素和反向因果关联等引起的偏倚,近年来被广泛应用于病因学研究。随着PUFAs全基因组关联研究的进展、MR研究设计以及相关统计方法的完善,不少研究采用MR研究探讨了PUFAs与恶性肿瘤、自身免疫性疾病等的发生风险。本文对国内外文献报道的PUFAs与疾病发生风险的MR研究现状进行综述,并探讨MR研究的优缺点,为进一步了解PUFAs对人类健康和疾病的影响提供依据。
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黄慧君
陈刚
钱雨
张凌芝
徐岚静
叶丁
毛盈颖
关键词 多不饱和脂肪酸孟德尔随机化单核苷酸多态性疾病风险    
Abstract:There are limitations in observational epidemiological studies when exploring the relationships between polyunsaturated fatty acids(PUFAs)and risk of diseases. Recent years have seen Mendelian randomization(MR)being widely employed in etiology research,since it can avoid bias caused by confounding factors and reverse causality in observational epidemiological studies. With the development of PUFAs related genome-wide association studies,MR study design and statistical Methods,MR studies have been conducted to investigate the relationships of PUFAs and risk of diseases including cancer and autoimmune disease. We systematically reviewed the published literature of MR studies on the association between PUFAs and risk of diseases,so as to discuss the underlying advantages and disadvantages of MR studies and to provide clues for further understanding the role of PUFAs in health and disease.
Key wordspolyunsaturated fatty acids    Mendelian randomization    single nucleotide polymorphisms    disease risk
收稿日期: 2019-09-23      出版日期: 2020-02-27
ZTFLH:  R181.2  
基金资助:国家自然科学基金(81973663,81602917); 浙江省自然科学基金项目(LQ15H260001); 浙江省科学技术协会人才项目(2018YCG003); 浙江中医药大学中青年科研创新基金(KC201905); 浙江中医药大学校级科研基金(2019ZR03)
作者简介: 毛盈颖,E-mail:myy@zcmu.edu.cn
引用本文:   
黄慧君, 陈刚, 钱雨, 张凌芝, 徐岚静, 叶丁, 毛盈颖. 多不饱和脂肪酸与疾病发生风险的孟德尔随机化研究进展[J]. 预防医学, 2020, 32(2): 152-154.
HUANG Huijun, CHEN Gang, QIAN Yu, ZHANG Lingzhi, XU Lanjing, YE Ding, MAO Yingying. Progress on the Mendelian randomization studies of polyunsaturated fatty acids and diseases. Preventive Medicine, 2020, 32(2): 152-154.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2020.02.011      或      http://www.zjyfyxzz.com/CN/Y2020/V32/I2/152
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