[1] KWINTA P,MITKOWSKA Z,KRUCZEK P,et al. Influence of the lactose free and lactose containing diet on prevalence of gram-negative sepsis and feeding intolerance in very low birth weight infants:double-blind randomized trial[J] . Prz Lek,2002,59(Suppl 1):63-66. [2] DI RIENZO T,D'ANGELO G,D'AVERSA F,et al. Lactose intolerance:from diagnosis to correct management[J] . Eur Rev Med Pharmacol Sci,2013,17(Suppl 2):18-25. [3] WESSEL M A,COBB J C,JACKSON E B,et al. Paroxysmal fussing in infancy,sometimes called colic[J] . Pediatrics,1954, 14(5):421-435. [4] KANABAR D,RANDHAWA M,CLAYTON P. Improvement of symptoms in infant colic following reduction of lactose load with lactase[J] . J Hum Nutr Diet,2001,14(5):359-363. [5] 叶环,胡宛如,张丽慧,等. 30例持续性啼哭婴儿的随访观察[J] . 中华预防医学杂志,2007,41(3):182. [6] 姜毅,李昕. 婴儿非感染性腹泻临床特点及乳糖不耐受的诊断方法探讨[J] . 中华临床医师杂志(电子版),2013,7(13):6112-6114. [7] 饶燕晓,叶环,俞栋,等. 新生儿乳糖酶缺乏发生率及相关因素分析[J] . 中华新生儿科杂志,2018,33(2):85-88. [8] GRENOV B,BRIEND A,SANGILD P T,et al. Undernourished children and milk lactose[J] . Food Nutr Bull,2016,37(1):85-99. [9] TORNIAINEN S,FREDDARA R,ROUTI T,et al. Four novel mutations in the lactase gene(LCT)underlying congenital lactase deficiency (CLD) [J] . BMC Gastroenterol,2009,9:8. [10] UCHIDA N,SAKAMOTO O,IRIE M,et al. Two novel mutations in the lactase gene in a Japanese infant with congenital lactase deficiency[J] . Tohoku J Exp Med,2012,227(1):69-72. [11] KUOKKANEN M,KOKKONEN J,ENATTAH N S,et al. Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency[J] . Am J Hum Genet,2006, 78(2):339-344. [12] DIEKMANN L,PFEIFFER K,NAIM H Y. Congenital lactose intolerance is triggered by severe mutations on both alleles of the lactase gene[J] . BMC Gastroenterol,2015,15:36. [13] HEYMAN M B,. Lactose intolerance in infants,children,and adolescents[J] . Pediatrics,2006,118(3):1279-1286. [14] JI J,SUNDQUIST J,SUNDQUIST K. Lactose intolerance and risk of lung,breast and ovarian cancers:aetiological clues from a population-based study in Sweden[J] . Br J Cancer,2015,112(1):149-152. [15] GRAND R J,MONTGOMERY R K,CHITKARA D K,et al. Changing genes; losing lactase[J] . Gut,2003,52(5):617- 619. [16] HERTZLER S,SAVAIANO D A,JACKSON K A,et al. Nutrient considerations in lactose intolerance[J] . Nutrition in the Prevention and Treatment of Disease,2013:757-772. [17] DOMíNGUEZ-JIMéNEZ J L,FERNáNDEZ-SUáREZ A. Diagnosis of lactose intolerance[J] . Med Clin (Barc),2017,148(6):262-264. [18] BAADKAR S V,MUKHERJEE M S,LELE S S. Study on influence of age,gender and genetic variants on lactose intolerance and its impact on milk intake in adult Asian Indians[J] . Ann Hum Biol,2014,41(6):548-553. [19] 邓燕勇. 杭州市区人群主观乳糖不耐受的流行病学调查及乳糖酶基因多态性研究[D] . 杭州:浙江大学,2009. [20] XU L,SUN H,ZHANG X,et al. The -22018A allele matches the lactase persistence phenotype in northern Chinese populations[J] . Scand J Gastroenterol,2010,45(2):168-174. [21] PENG M S,HE J D,ZHU C L,et al. Lactase persistence may have an independent origin in Tibetan populations from Tibet,China[J] . J Hum Genet,2012,57(6):394-397. [22] HU Y,GUI L,CHANG J,et al. The incidence of infants with rotavirus enteritis combined with lactose intolerance[J] . Pak J Pharm Sci,2016,29(1 Suppl):321-323. [23] REYNOSO-ROBLES R,PONCE-MACOTELA M,ROSAS- LóPEZ L E,et al. The invasive potential of Giardia intestinalis in an in vivo model[J] . Sci Rep,2015,5:15168. [24] 刘欣竹,王君,郭亚楠. 发育型乳糖不耐受症1例[J] . 中国医药导报,2016,13(8):174-176. [25] MONTGOMERY R K,MULBERG A E,GRAND R J. Development of the human gastrointestinal tract:Twenty years of progress[J] . Gastroenterology,1999,116(3):702-731. [26] GLASS H C,COSTARINO A T,STAYER S A,et al. Outcomes for extremely premature infants[J] . Anesth Analg,2015,120(6):1337-1351. [27] 夏婧,吴捷,魏克伦. 无乳糖奶粉辅助治疗婴儿急性腹泻病的疗效研究[J] . 国际儿科学杂志,2015,42(5):592-594. [28] JOHNSON A O,SEMENYA J G,BUCHOWSKI M S,et al. Adaptation of lactose maldigesters to continued milk intakes[J] . Am J Clin Nutr,1993,58(6):879-881. [29] GRIFFIN M P,HANSEN J W. Can the elimination of lactose from formula improve feeding tolerance in premature infants[J] . J Pediatr,1999,135(5):587-592. [30] OAK S J,JHA R. The effects of probiotics in lactose intolerance:A systematic review[J] . Crit Rev Food Sci Nutr,2018:1-9. [31] 陈青. 双歧杆菌及酪酸梭菌联合治疗婴儿继发性乳糖不耐受72例[J] . 天津医药,2007,35(3):237. [32] 唐静. 双歧杆菌治疗婴幼儿轮状病毒肠炎继发性乳糖不耐受的疗效[J] . 中国实用医刊,2013,40(7):112. [33] 江爱清,余蓉,陈春花. 布拉酵母菌联合去乳糖奶粉治疗婴幼儿继发性乳糖不耐受症疗效探讨[J] . 中国社区医师,2016,32(22):98-99. [34] SAVAIANO D A,RITTER A J,KLAENHAMMER T R,et al. Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide(RP-G28):a randomized,double- blind clinical trial[J] . Nutr J,2013,12:160. [35] BAYLESS T M,BROWN E,PAIGE D M. Lactase non-persistence and lactose intolerance[J] . Curr Gastroenterol Rep,2017,19(5):23. [36] DI PIERRO F,BERTUCCIOLI A,MARINI E,et al. A pilot trial on subjects with lactose and/or oligosaccharides intolerance treated with a fixed mixture of pure and enteric-coated α- and β-galactosidase[J] . Clin Exp Gastroenterol,2015,8:95-100. [37] DURING M J,XU R,YOUNG D,et al. Peroral gene therapy of lactose intolerance using an adeno-associated virus vector[J] . Nat Med,1998,4(10):1131-1135.