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| Strategies and practices of tuberculosis preventive treatment for latent tuberculosis infection in Huzhou City |
| REN Feilin1, YANG Zhongrong1, SUN Xiuxiu1, ZHANG Sichao1, JIN Meihua1, SHEN Jianyong1, DING Zhongming1, WEN Dong2, ZHENG Pingming2, ZHANG Peng1
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1. Huzhou Center for Disease Control and Prevention, Huzhou, Zhejiang 313000, China;
2. Huzhou Municipal Health Commission, Huzhou, Zhejiang 313000, China |
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Abstract The World Health Organization (WHO) emphasizes that tuberculosis preventive treatment is a key measure for ending the tuberculosis epidemic. In 2023, Huzhou City initiated the construction of Zero Tuberculosis City based on the pilot program of Zero Tuberculosis Communities in Zhejiang Province, and established a three-level tuberculosis preventive treatment system for latent tuberculosis infection (LTBI) at the municipal, county (district), and township (subdistrict) levels. Strategies including formulating standards and norms, promoting preventive treatment clinics at all levels, improving staffing and clarifying work responsibilities were implemented to strengthen active intervention and management of LTBI and improve the standardization of preventive treatment. From 2023 to 2024, a total of 27 535 individuals tested positive for Mycobacterium tuberculosis (MTB) in Huzhou City. The acceptance rate of preventive treatment was 34.82%, and the completion rate was 57.89%. During follow-up, the incidence density of active pulmonary tuberculosis among MTB-positive individuals who did not receive preventive treatment was 393.83/105 person-years, while that among individuals who received preventive treatment but interrupted treatment was 293.83/105 person-years, and that among individuals who received and completed preventive treatment was 46.08/105 person-years. Practices have shown that the LTBI preventive treatment system constructed in Huzhou City features strong accessibility and high operability, which has effectively expanded the coverage of interventions for high-risk groups, significantly reduced the risk of active pulmonary tuberculosis among MTB-positive individuals, and provided a replicable and promotable practical paradigm for LTBI prevention and control nationwide. In the future, Huzhou City will continue to rely on the primary medical and health network to optimize the whole-process standardized management of LTBI, leverage smart prevention and control technologies, optimize diagnosis and treatment services and cross-regional linkage mechanisms, continuously consolidate the achievements of the Zero Tuberculosis City initiative, steadily reduce the regional tuberculosis epidemic, and contribute to the achievement of the strategic goal of ending the tuberculosis epidemic.
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Received: 26 March 2026
Revised: 05 September 2026
Published: 22 September 2026
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[1] Hartman-Adams H,Clark K,Juckett G.Update on latent tuberculosis infection[J].Am Fam Physician,2014,89(11):889-896.
[2] Zenner D,Beer N,Harris R J,et al.Treatment of latent tuberculosis infection:an updated network meta-analysis[J].Ann Intern Med,2017,167(4):248-255.
[3] World Health Organization.WHO consolidated guidelines on tuberculosis:module 1:prevention-tuberculosis preventive treatment second section[R].Geneva:WHO,2024.
[4] 徐彩红,赵雁林.中国结核病预防性治疗指南[M].北京:人民卫生出版社,2023.
[5] 湖州市卫生健康委员会.湖州市结核病防治管理办法[Z].2013.
[6] 吴倩,王伟,张钰,等.浙江省无结核社区评价指标体系构建[J].中国防痨杂志,2025,47(3):331-337.
[7] 郑平明,金玫华,丁忠明,等.浙江省湖州市“无结核城市”建设实践与思考[J].中国防痨杂志,2024,46(10):1193-1197.
[8] 湖州市卫生健康委员会办公室.湖州市卫生健康委办公室关于印发结核病预防性治疗门诊建设标准的通知[Z].2023.
[9] 湖州市疾病预防控制中心.关于印发湖州市结核病预防性治疗对象社区随访服务规范(试行)的通知[Z].2024.
[10] T/CHATA 028—2022 结核分枝杆菌潜伏感染人群预防性治疗规范[S].
[11] T/CHATA 052—2025 基层医疗卫生机构结核病预防性治疗门诊建设规范[S].
[12] 马艳,陆伟,高磊,等.终止结核病流行须加强结核分枝杆菌潜伏感染高危人群筛查和预防性治疗的管理[J].中国防痨杂志,2022,44(3):209-214.
[13] 丁厅厅,许兴龙,李霞,等.基层医疗卫生机构开设结核病预防性治疗门诊的SWOT分析[J].中国卫生质量管理,2025,32(9):107-110.
[14] 肖筱,陈彬,刘巧,等.我国结核分枝杆菌潜伏感染筛查与预防性治疗进展[J].预防医学,2026,38(5):433-437.
[15] 中华人民共和国国家疾病预防控制局,中华人民共和国国家卫生健康委员会,中华人民共和国国家发展和改革委员会,等.关于印发全国结核病防治规划(2024—2030年)的通知[EB/OL].[2026-09-05].https://www.gov.cn/zhengce/zhengceku/202412/content_6991217.htm.
[16] 陈彬.关口前移,创新驱动,迈向终结结核流行[J].预防医学,2026,38(3):217-221. |
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