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| Research progress on changes of postpartum immune status and clinical cure strategies among women with chronic hepatitis B virus infection |
| CHEN Wei, LIU Shourong
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| The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China |
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Abstract Achieving clinical cure can significantly improve long-term adverse outcomes in patients and has become the ideal treatment goal for chronic hepatitis B (CHB) . However, this goal is only realized in a minority of patients with advantageous baseline characteristics. Clinical studies indicate that the postpartum relief of immunosuppression in women with chronic hepatitis B virus (HBV) infection may increase the chance of HBV clearance, suggesting this group could be a potential advantaged population for hepatitis B clinical cure. Therefore, identifying favorable candidate subgroups among pregnant women with chronic HBV infection, selecting the appropriate timing for antiviral therapy, and choosing optimal treatment regimens are crucial for further improving the cure rate. This article reviews literature from databases such as CNKI and PubMed (2010-2025) on maternal immune characteristics and antiviral therapy, summarizing postpartum immune changes in chronic HBV-infected mothers, the efficacy and adverse effects of different antiviral regimens, and key factors influencing clinical cure, aiming to provide a basis for developing individualized treatment strategies CHB; patients and enhancing the clinical cure rate in practice.
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Received: 04 November 2025
Revised: 05 February 2026
Published: 23 March 2026
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