ObjectiveTo investigate an imported case of Zika virus disease in Wenzhou City, to explore the source of infection,to analyse the problems during surveillance and diagnosis, and to provide evidence for prevention and control of Zika virus disease. MethodsBy field investigation, medical records of the patient were collected and a face-to-face interview was conducted; blood, urine and saliva samples within 48 h were collected for RNA detection; assess the risk of disease spreading by mosquito surveillance and take control measures. ResultsThe onset of the disease was on the patient's way home from aboard on February 21^st,2016.Before then, She lived in Paramaribo, the capital of Suriname in South America, which is an epidemic area of Zika virus.The patient had exposure history,with red,diffuse rash on her head,face,neck and limbs,and once was diagnosed as allergic eruption because of no fever. The two blood samples were both tested negative yet We detected urine and saliva samples showed positive. With the evidence above, the patient was finally diagnosed as an imported Zika virus case. The spreading risk of this case was low due to the low temperature. Conclusionthere may be cases without fever or with blood sample tested RNA negative. As the weather gets warmer, missed diagnosis should be aware of, or the risk of spreading through mosquitos would increase. Therefore, in order to further improvement should lie in mosquito control and disease surveillance.

ObjectiveTo investigate the prevalence of urinary incontinence and its effect on life quality among female adults in Hangzhou, and to provide evidence to the control of female urinary incontinence. MethodsA questionnaire survey was performed in Gongshu and Xiacheng districts in Hangzhou from October 2013 to June 2014, and 4 563 women aged over 20 years were interviewed through a questionnaire including International Consultation on Incontinence Questionnaire Lower Urinary Tract, IQ-FLUTS and demographic information. Single and multi factor logistic regression analysis were used to analyze the risk factors of urinary incontinence. ResultsA total of 4 785 questionnaires were sent, and 4 563 effective questionnaires were recovered,with a recovery rate of 95.4%.The prevalence of urinary incontinence was 33.5%(1 530/4 563), and female with older age tended to have a higher prevalence of UI(P<0.01). Among which stress urinary incontinence(SUI),urge incontinence(UUI)and mixed urinary incontinence(MUI) were accounted for 20.2%(922/4 563), 3.0%(135/4 563) and 10.3%(473/4 563) respectively.UUI and MUI had a greater effect on quality of life. According to the multi factor logistic regression analysis, gravidity, age, constipation, pelvic surgery and fat(BMI>24) were risk factors for urinary incontinence (P<0.05).ConclusionBecause of the high prevalence of urinary incontinence among female adults, more attention should be paid to urinary incontinence suffers in order to improve the quality of life of female adults.

ObjectiveTo investigate the cytotoxicity and oxidative stress of ambient fine particulate matter (PM2.5) and water-soluble fraction of PM2.5 on human bronchial epithelial cells (HBE ). MethodsPM2.5 samples were collected in the urban area of Hangzhou. Then the water-soluble fraction was extracted from PM2.5. After HBE cells were exposed to PM2.5 and its water-soluble fraction at the doses of 0, 100, 250, 500, 1 000, 1 500 and 2 000 μg/mL for 24 h, CCK-8 (cell counting kit-8 )assay was conducted to examine the cytotoxicity of the PM2.5 and its water-soluble fraction. The oxidative damage induced by PM2.5 and its water-soluble fraction on HBE cells was then evaluated with lipid peroxidation, the superoxide dismutase (SOD) activity, and the levels of glutathione peroxidase (GSH-Px). ResultsThe PM2.5 and its water-soluble fraction reduced the viability of HBE cells in a dose-dependent manner. When the PM concentrations were 200, 400 and 800 μg/mL, the SOD activity of the HBE cells decreased significantly, as compared with the control group (P< 0.05). Also, the malondialdehyde (MDA) levels of the HBE cells significantly increased at the doses of 200, 400 and 800 μg/mL (P< 0.05). However, there were no significant differences of GSH-Px activity among the groups. ConclusionThe PM2.5 and its water-soluble fraction could induce cytotoxic and oxidative damage effects on the HBE cells.

ObjectiveTo learn the parents' acceptance of charge vaccines and the influencing factors. MethodsTotally 1869 parents with children of 0-6 years old were selected with typical sampling and were investigated face to face.The awareness, acceptance and influencing factors and service demands were analyzed. ResultsThere were 80.20% of the parents willing to give their children the charge vaccination.Compared with the local residents group, the other province resident group and other city resident group had a low probability to have charge vaccination (OR=0.777,OR= 0.530). Parents who usually concerned about vaccine information were more likely to be vaccinated with charge vaccine(OR= 1.307).Compared with other inoculation station, the stations which parents enjoying convenient service have higher inoculation rate(OR =1.673 ). ConclusionMost parents have accepted the charge vaccination for their children. Health information and service quality of vaccination station are important influencing factors for accessibility of charge vaccination.

ObjectiveTo analyze the status of education and health service related to sexual and reproductive health among early adolescent students in Zhejiang Province and to provide scientific evidence for puberty education and health service. MethodsA cross-sectional survey was conducted among 1 312 primary students from grade 4 to 6 in Zhejiang Province, with stratified cluster sampling method. A self-made questionnaire was used to collect the information of their demographic characteristics and the utilization and demand situation of education and health service related to sexual and reproductive health. ResultsAmong the students, 37.33 percent of the students had never got the sexual and reproductive health knowledge from school, and only 32.92 percent of them said that their school had provided adolescent health care service, and 34.32 percent of them was not satisfied with this service. And 48.75 percent of them said that their parents had never communicated SRH topics with them, meanwhile, 35.94 percent of them had never asked their parents SRH questions, and only 16.96 percent of them felt easy when they communicate SRH topics with their parents, and only 23.69 percent of them hope to communicate SRH topics with their parents. Meanwhile, 59.65 percent of them had never communicated SRH topics with their peers, and 10.67 percent of them had gone to hospital due to pubertal development and reproductive health problems, and 59.41 percent of them thought it necessary to open adolescent reproductive health clinics in society. ConclusionSchool education, family education, peer education and social health service related to sexual and reproductive health among early adolescent students is relatively backward, and there is a big gap between the existing service and the demand of adolescents.

ObjectiveTo evaluate the effect of 3 different kinds of propaganda modes of charge vaccines on changing knowledge, attitude and behavior of community residents, and to explore the effective propaganda mode of vaccination. MethodsSanjiang, Jiangnan and Sumeng were selected as pilot streets, respectively. And "mother class" (A) mode, vaccination clinics "inform-booking" (B) mode and the community responsible doctor recommended mode (C) mode were used to carry out intervention. Intervention time was from March to September, 2014. Awareness rate, necessity awareness rate, compliance rate and vaccination rate of the children of school age were used to evaluate effect of 3 propaganda modes. ResultsThere were no significant differences in demographic characteristics among three modes(P>0.05). Through intervention of A, B mode, the awareness knowledge, necessity awareness and willingness to vaccination were improved (P<0.05), while the other indicators were not improved through C mode intervention except for 4 vaccine related knowledge (P<0.05). After controlling for the time factor, the improving effect of related knowledge, attitude and behavior of charge vaccine through A and B modes were better than those through C mode(P<0.05). ConclusionThe effect of "mother class" mode, the vaccination clinics "inform-booking" mode to carry out the charge vaccine propaganda is significant, but the community responsible doctor recommended mode needs to be improved.

ObjectiveTo learn the protein intake status of adults in Zhejiang Province and to investigate the relationship between the protein intake and influencing factors, and in order to provide a scientific basis for improving adult protein intake. MethodsData were selected from the 2010—2012 Chinese National Nutrition and Health Survey in Zhejiang province. Data were gained through medical examination and the method of 3 day 24-hour dietary recall and food weighted record. Descriptive analysis was conducted. ResultsThere were 1 160 men (48.09%) and 1 252 women (51.91%) in 2 412 cases in this analysis. The average protein intake per day was 71.87 g for per reference man, and the intake quartile was 66.06(51.17-85.93) g/d and 38.14% of adults were not achieved the Recommended Nutrient Intake (RNI). The multi factor logistic regression analysis showed that age, region, income and occupation were the main factors affecting protein intake. Age was a risk factor, while income was a protective factor. Big cities were more easily to have insufficient protein intake than median and small cities. Students, agriculture, housework and other groups of adults were more easily to have insufficient protein intake. And 30.70% of dietary protein was from cereal, and 39.70% was from animal food. Sources of dietary protein were statistical significant among different areas and age. Protein intake from cereal among young people (29.60%), old people (29.95%), and people living in big cities (19.81%) was low. Protein intake from cereal among people living in medium and small cities (10.40%) was high. Young people (43.12%) and people living in big cities (52.87%) had higher animal source protein. ConclusionThe protein intake of adults in Zhejiang Province was not achieved the RNI. It is important to conduct health educations according to the protein intake problems of different groups to improve their protein intake status.

ObjectiveTo explore the current profile of drowning related high risk behaviors among the floating children in Ningbo City and to identify the risk factors on these behaviors. MethodsA total of 7 600 students from grade 1-9 in eight urban migrant workers' children schools were recruited and surveyed by the questionnaires. And the logistic regression model was used for the analysis of risk factors. ResultsIn last one year, without adult supervision, the incidence rate of drowning related high risk behaviors was 27.53%. The results of multivariate logistic regression showed that males (OR=2.30,95%CI:1.99~2.65), senior grade (OR=1.23,95%CI:1.18~1.27), other juvenile companion on the way to schools (OR=1.26,95%CI:1.06~1.51), being able to swim (OR=2.09,95%CI:1.77~2.46) and there being the open water around school and home (OR=1.75,95%CI:1.52~2.00) could increase the incidence of drowning related high risk behaviors. And higher awareness of drowning prevention (OR=0.99,95%CI:0.98~0.99), higher rate of correct attitude (OR=0.99,95%CI:0.98~0.99), getting along well with schoolmates (OR=0.69,95%CI:0.51~0.95) and with family members (OR=0.33,95%CI:0.24~0.46) could reduce the incidence of drowning related high risk behaviors. ConclusionThe incidence rate of drowning related high risk behaviors was high among the floating children in Ningbo City, and males, being able to swim might increase the occurrence of high risk behaviors.

ObjectiveTo explore the association among serum insulin, IGFBP3, and endometrial cancer risk in Chinese women. MethodsSerum insulin and IGFBP3 were detected by ELISA method in 206 patients with endometrial carcinoma and 310 healthy women. Using logistic regression analysis after adjustments for BMI, serum glucose and triglycerides to explore the association among the two indicators and the risk of endometrial carcinoma. ResultsIncreased insulin were found in the women with endometrial carcinomas as compared with that of controls [Mean±SD:insulin (14.84±16.72) uU·mL^-1 in women with cancer versus (8.13±9.40) uU·mL^-1 in controls, P<0.01]. However, serum IGFBP3 was not significantly higher in women with endometrial cancer [Mean±SD:IGFBP3 (1.76±2.44) mg·L^-1 in women with cancer versus (1.57±1.80) mg·L^-1in controls, P>0.05]. The risk for endometrial cancer was significantly higher in the upper quartile relevant to the lowest quartile of serum insulin, and lower in the upper quartile of serum IGFBP3 (P<0.05). Logistic regression analysis showed that serum insulin was the risk factor of endometrial carcinoma(OR=2.34, 95%CI:1.32-4.14), after adjusting obesity/overweight status, serum glucose, total cholesterol, total glyceride, and HDL-C. ConclusionHyperinsulinemia was an independent risk factor for endometrial carcinomas in Chinese women. However, the protective role of increased serum IGFBP3 should be validated further.

ObjectiveTo explore the prognostic value of preoperative neutrophil-to-lymphocyte ratio and derived neutrophil-to-lymphocyte ratio in colorectal cancer (CRC) individuals. MethodsThe clinical pathological data and preoperative blood routine test results were collected from medical records, and 5 year follow up was performed in a total of 555 surgically resected CRC cases. Receiver operative curve (ROC) was used to calculate NLR and d-NLR cut-off value, and Kaplan-Meier curve and multiple COX regression were selected to evaluate the influence of preoperative NLR and d-NLR on clinical outcome of CRC cases and prognostic predictive nomogram was established to evaluate the predictive value of NLR and d-NLR. ResultsUsing overall survival (OS) as an endpoint, the optimal cut-off values of NLR and d-NLR were 3.21 (Sensitivity=0.752, specificity=0.753, AUC=0.762) and 2.12 (sensitivity=0.721, specificity=0.683, AUC=0.720), respectively. Preoperative NLR and d-NLR were significantly associated with free-recurrent survival (RFS) and OS(P<0.01). NLR and d-NLR were independent factors for prediction of RFS (HR_NLR =2.53, HR_d-NLR=1.60) and OS (HR_NLR=2.75, HR_d-NLR=2.11) in II-III stage preoperative CRC patients. The C-indexes of RFS and OS predictive nomograms including NLR and d-NLR were 0.851 and 0.836, and C-indexes without NLR and d-NLR were 0.801 and 0.793, respectively. ConclusionThis results indicated that RFS and OS of the patients with preoperative high NLR and d-NLR were significantly shorter than those with relative low NLR and d-NLR, and they were independent prognostic predictive factors for RFS and OS, and nomograms including NLR and d-NLR could significantly improve the prognostic predictive efficacy in postoperative CRC individuals.

ObjectiveThe aim of the study was to examine the psychometric properties of the Chinese revised version of Barratt Impulsiveness Scale 11th (BIS-11) in Chinese college student with a web-based survey. MethodsA total of 2 295 college students were enrolled in the survey,and were divided into two groups.The first group was used for item and factor analysis, and the second group was used for confirmatory factors analysis. ResultsItem analysis indicated that BIS-11 had satisfactory item discrimination, except the item 29. Three-factor model of BIS-11 was well documented with exploratory factor analysis (explained 45.526% of total variance) and confirmatory factor analysis (GFI, AGFI, TLI, CFI, RMSEA was 0.872, 0.851, 0.853, 0.864, 0.064, respectively). The internal consistency of the total scale and the three subscales using coefficient alpha was in the range of 0.833-0.913. The split-half reliability of the total scale and the three subscales using Spearman-Brown Coefficient was in the range of 0.827-0.907. Furthermore, the female college students in the present study had higher scores on the total scale, cognitive (attention) impulsiveness factor, and motor impulsiveness factor than the male college student (P<0.01). The individuals with GHQ-12 (the twelve-item General Health Questionnaire) screen-positive had higher scores on the total scale and the three factors than the subjects with GHQ-12 screen-negative (P<0.01). ConclusionThe results of present study suggested that the Chinese revised version of the Barratt Impulsiveness Scale 11th could be used as a tool of impulsiveness assessment in web-based survey.